Stem cells derived from the pelvic bone could preserve heart function, revealed a latest research. The study assesses the efficacy and safety of infusing stem cells collected from bone marrow of patient into the artery in the heart which may have caused the heart attack.
Doctors and other clinicians from the Orlando Health Heart Institute are investigating the use of stem cells derived from pelvic bone marrow to restore tissue and improve heart function after muscle damage from heart attacks. The infusion process starts with a catheter put in through a slit in the groin.
With the help of an X-ray camera that steers doctors to position the catheter in the heart artery where the stent was positioned. Then a balloon is inflated within the stent and the infusion comes to pass in the area impacted by the heart attack. Before infusion, patients are screened using an electrocardiogram, a cardiac MRI and a cardiac nuclear test.
Subsequent to the compulsory screenings, patients have to undergo a mini-bone marrow procedure, in which the stem cells are removed from the bone marrow in their pelvic bone, with the help of a special needle. Then stem cells are processed in the pipeline for infusion. As study is randomized, patients in placebo group are infused with AMR-001.
It is a cell therapy produce consist of stem cell taken from one’s own bone marrow. Patients in placebo group will have their bone marrow frozen and stored and available to them for clinical use or when they need bone marrow for any cause. Nearly one hundred and sixty patients will participate in this national study at approximately thirty-four location.
Dr Vijaykumar S. Kasi, MD, PhD, principal investigator for clinical trial at ORMC, stated as stem cells are immature cells they have the potential to develop into new blood vessels and preserve cardiac muscle cells. By infusing certain stem cells into the area of the heart muscle that has been damaged from a heart attack, tissue can be preserved and heart function restored.
Stem cell therapy is part of the movement from treatment to cure and has the potential to conquer boundaries and expenses of heart transplants and offers hope for patients who are desperately praying for another chance at life, added Dr Kasi.
STEMI or Segment Elevation Myocardial Infarction is a critical form of heart attack occurred because of a prolonged period of blocked supply of blood affecting a large area of the heart muscle and causing changes in the blood levels of key chemical markers.