In a novel study researchers have identified a sequence of gene variation that together play a key role in the development of normal breast cancer. The research team from Singapore believes that these are connected to the production of oestrogen which recognized as significant factor in form of breast cancer that distress post menopausal women.
In a study trail researcher observed the genetic makeup of thousands of healthy women and those suffering from breast cancer in Sweden and Finland. More than one hundred and twenty genetic variations in fifteen different genes were found that they said seemed to be connected with women’s risk of developing oestrogen receptor positive breast cancer.
The variations are found in segment of DNA close to the gene responsible for producing oestrogen and proposal is that variations can play a combined role in the making of female sex hormones. It is already recognized that women with late menopause or women who start menstruating early, both have an augmented risk of breast cancer as they have longer exposure to oestrogen.
Breast cancer genes have been recognized as example BRCA1, BRCA2, P53 and ATM. They are recognized mainly in breast cancers of young women, said study leader Dr Edison Liu from the Genome Institute of Singapore. They are finding the hereditary amplifiers for breast cancer in postmenopausal women.
They have also identified the same hereditary variations in women suffering uterus cancer where oestrogen exposure is also measured key. They know that oestrogen levels play a significant job in the growth of breast and womb cancer. It will bring them closer to realize many delicate genetic alterations that affect women’s risk of these conditions.
By understanding these changes help to identify women most at risk so they can be offered tailored advice, screening and treatments in the future, explained science communications officer, Nell Barrie from Cancer Research UK.